diff --git a/assets/js/src/segments/dynamic/list.jsx b/assets/js/src/segments/dynamic/list.jsx
index fac6287ac1..00f7288702 100644
--- a/assets/js/src/segments/dynamic/list.jsx
+++ b/assets/js/src/segments/dynamic/list.jsx
@@ -91,6 +91,21 @@ const itemActions = [
         {MailPoet.I18n.t('edit')}
       </Link>
     ),
+    display: (item) => (
+      !item.is_plugin_missing
+    ),
+  },
+  {
+    name: 'edit_disabled',
+    className: 'mailpoet-hide-on-mobile mailpoet-disabled',
+    link: (item) => (
+      <Link to={`/edit-segment/${item.id}`}>
+        {MailPoet.I18n.t('edit')}
+      </Link>
+    ),
+    display: (item) => (
+      item.is_plugin_missing
+    ),
   },
   {
     name: 'view_subscribers',
@@ -126,12 +141,22 @@ function renderItem(item, actions) {
       <td data-colname={MailPoet.I18n.t('description')}>
         <abbr>{ item.description }</abbr>
       </td>
-      <td className="column mailpoet-hide-on-mobile" data-colname={MailPoet.I18n.t('subscribersCountColumn')}>
-        { parseInt(item.count_all, 10).toLocaleString() }
-      </td>
-      <td className="column mailpoet-hide-on-mobile" data-colname={MailPoet.I18n.t('subscribed')}>
-        { parseInt(item.count_subscribed, 10).toLocaleString() }
-      </td>
+      { item.is_plugin_missing
+        ? (
+          <td colSpan="2" className="column mailpoet-hide-on-mobile" data-colname={MailPoet.I18n.t('missingPluginMessageColumn')}>
+            { item.missing_plugin_message }
+          </td>
+        )
+        : (
+          <>
+            <td className="column mailpoet-hide-on-mobile" data-colname={MailPoet.I18n.t('subscribersCountColumn')}>
+              { parseInt(item.count_all, 10).toLocaleString() }
+            </td>
+            <td className="column mailpoet-hide-on-mobile" data-colname={MailPoet.I18n.t('subscribed')}>
+              { parseInt(item.count_subscribed, 10).toLocaleString() }
+            </td>
+          </>
+        )}
       <td className="column-date mailpoet-hide-on-mobile" data-colname={MailPoet.I18n.t('updatedAtColumn')}>
         { MailPoet.Date.short(item.created_at) }
         <br />
diff --git a/lib/API/JSON/ResponseBuilders/DynamicSegmentsResponseBuilder.php b/lib/API/JSON/ResponseBuilders/DynamicSegmentsResponseBuilder.php
index 5b37e6dea6..0e1cb9b9d8 100644
--- a/lib/API/JSON/ResponseBuilders/DynamicSegmentsResponseBuilder.php
+++ b/lib/API/JSON/ResponseBuilders/DynamicSegmentsResponseBuilder.php
@@ -5,6 +5,7 @@ namespace MailPoet\API\JSON\ResponseBuilders;
 use MailPoet\Entities\DynamicSegmentFilterEntity;
 use MailPoet\Entities\SegmentEntity;
 use MailPoet\Entities\SubscriberEntity;
+use MailPoet\Segments\SegmentDependencyValidator;
 use MailPoet\Segments\SegmentSubscribersRepository;
 use MailPoet\WP\Functions;
 
@@ -20,18 +21,24 @@ class DynamicSegmentsResponseBuilder {
   /** @var SegmentSubscribersRepository */
   private $segmentSubscriberRepository;
 
+  /** @var SegmentDependencyValidator */
+  private $segmentDependencyValidator;
+
   public function __construct(
     Functions $wp,
     SegmentSubscribersRepository $segmentSubscriberRepository,
-    SegmentsResponseBuilder $segmentsResponseBuilder
+    SegmentsResponseBuilder $segmentsResponseBuilder,
+    SegmentDependencyValidator $segmentDependencyValidator
   ) {
     $this->segmentsResponseBuilder = $segmentsResponseBuilder;
     $this->segmentSubscriberRepository = $segmentSubscriberRepository;
     $this->wp = $wp;
+    $this->segmentDependencyValidator = $segmentDependencyValidator;
   }
 
   public function build(SegmentEntity $segmentEntity) {
     $data = $this->segmentsResponseBuilder->build($segmentEntity);
+    $data = $this->addMissingPluginProperties($segmentEntity, $data);
     // So far we allow dynamic segments to have only one filter
     $filter = $segmentEntity->getDynamicFilters()->first();
     if (!$filter instanceof DynamicSegmentFilterEntity) {
@@ -48,11 +55,29 @@ class DynamicSegmentsResponseBuilder {
     return $data;
   }
 
+  private function addMissingPluginProperties(SegmentEntity $segment, array $data): array {
+    $missingPlugins = $this->segmentDependencyValidator->getMissingPluginsBySegment($segment);
+    if ($missingPlugins) {
+      $missingPlugin = reset($missingPlugins);
+      $data['is_plugin_missing'] = true;
+      $data['missing_plugin_message'] = sprintf(
+        __('Activate the %s plugin to see the number of subscribers and enable the editing of this segment.', 'mailpoet'),
+        $missingPlugin
+      );
+    } else {
+      $data['is_plugin_missing'] = false;
+      $data['missing_plugin_message'] = null;
+    }
+    return $data;
+  }
+
   private function buildListingItem(SegmentEntity $segment): array {
     $data = $this->segmentsResponseBuilder->build($segment);
+    $data = $this->addMissingPluginProperties($segment, $data);
     $data['subscribers_url'] = $this->wp->adminUrl(
       'admin.php?page=mailpoet-subscribers#/filter[segment=' . $segment->getId() . ']'
     );
+
     $data['count_all'] = $this->segmentSubscriberRepository->getSubscribersCount((int)$segment->getId());
     $data['count_subscribed'] = $this->segmentSubscriberRepository->getSubscribersCount((int)$segment->getId(), SubscriberEntity::STATUS_SUBSCRIBED);
     return $data;
diff --git a/lib/DI/ContainerConfigurator.php b/lib/DI/ContainerConfigurator.php
index 94cf3b3aa5..2895ad42ef 100644
--- a/lib/DI/ContainerConfigurator.php
+++ b/lib/DI/ContainerConfigurator.php
@@ -261,6 +261,7 @@ class ContainerConfigurator implements IContainerConfigurator {
     $container->autowire(\MailPoet\Segments\SegmentListingRepository::class)->setPublic(true);
     $container->autowire(\MailPoet\Segments\SegmentsSimpleListRepository::class)->setPublic(true);
     $container->autowire(\MailPoet\Segments\SegmentSaveController::class)->setPublic(true);
+    $container->autowire(\MailPoet\Segments\SegmentDependencyValidator::class)->setPublic(true);
     $container->autowire(\MailPoet\Segments\DynamicSegments\DynamicSegmentsListingRepository::class)->setPublic(true);
     $container->autowire(\MailPoet\Segments\DynamicSegments\FilterHandler::class)->setPublic(true);
     $container->autowire(\MailPoet\Segments\DynamicSegments\Filters\EmailAction::class)->setPublic(true);
diff --git a/lib/Segments/DynamicSegments/FilterHandler.php b/lib/Segments/DynamicSegments/FilterHandler.php
index 428ecb2c93..dc0c8c6abe 100644
--- a/lib/Segments/DynamicSegments/FilterHandler.php
+++ b/lib/Segments/DynamicSegments/FilterHandler.php
@@ -11,6 +11,7 @@ use MailPoet\Segments\DynamicSegments\Filters\EmailAction;
 use MailPoet\Segments\DynamicSegments\Filters\UserRole;
 use MailPoet\Segments\DynamicSegments\Filters\WooCommerceCategory;
 use MailPoet\Segments\DynamicSegments\Filters\WooCommerceProduct;
+use MailPoet\Segments\SegmentDependencyValidator;
 use MailPoetVendor\Doctrine\DBAL\Query\QueryBuilder;
 use MailPoetVendor\Doctrine\ORM\EntityManager;
 
@@ -30,18 +31,23 @@ class FilterHandler {
   /** @var EntityManager */
   private $entityManager;
 
+  /** @var SegmentDependencyValidator */
+  private $segmentDependencyValidator;
+
   public function __construct(
     EntityManager $entityManager,
     EmailAction $emailAction,
     UserRole $userRole,
     WooCommerceProduct $wooCommerceProduct,
-    WooCommerceCategory $wooCommerceCategory
+    WooCommerceCategory $wooCommerceCategory,
+    SegmentDependencyValidator $segmentDependencyValidator
   ) {
     $this->emailAction = $emailAction;
     $this->userRole = $userRole;
     $this->wooCommerceProduct = $wooCommerceProduct;
     $this->wooCommerceCategory = $wooCommerceCategory;
     $this->entityManager = $entityManager;
+    $this->segmentDependencyValidator = $segmentDependencyValidator;
   }
 
   public function apply(QueryBuilder $queryBuilder, SegmentEntity $segment): QueryBuilder {
@@ -54,7 +60,12 @@ class FilterHandler {
         ->createQueryBuilder()
         ->select("DISTINCT $subscribersTable.id as inner_subscriber_id")
         ->from($subscribersTable);
-      $this->applyFilter($subscribersIdsQuery, $filter);
+      // When a required plugin is missing we want to return empty result
+      if ($this->segmentDependencyValidator->getMissingPluginByFilter($filter)) {
+        $subscribersIdsQuery->andWhere('1 = 0');
+      } else {
+        $this->applyFilter($subscribersIdsQuery, $filter);
+      }
       $filterSelects[] = $subscribersIdsQuery->getSQL();
       $queryBuilder->setParameters(array_merge(
         $subscribersIdsQuery->getParameters(),
diff --git a/lib/Segments/SegmentDependencyValidator.php b/lib/Segments/SegmentDependencyValidator.php
new file mode 100644
index 0000000000..0f62ad8702
--- /dev/null
+++ b/lib/Segments/SegmentDependencyValidator.php
@@ -0,0 +1,55 @@
+<?php
+
+namespace MailPoet\Segments;
+
+use MailPoet\Entities\DynamicSegmentFilterData;
+use MailPoet\Entities\DynamicSegmentFilterEntity;
+use MailPoet\Entities\SegmentEntity;
+use MailPoet\WP\Functions as WPFunctions;
+
+class SegmentDependencyValidator {
+  private const REQUIRED_PLUGINS_BY_TYPE = [
+    DynamicSegmentFilterData::TYPE_WOOCOMMERCE => [
+      'id' => 'woocommerce/woocommerce.php',
+      'name' => 'WooCommerce',
+    ],
+  ];
+
+  /** @var WPFunctions */
+  private $wp;
+
+  public function __construct(WPFunctions $wp) {
+    $this->wp = $wp;
+  }
+
+  /**
+   * @return string[]
+   */
+  public function getMissingPluginsBySegment(SegmentEntity $segment): array {
+    $missingPlugins = [];
+    foreach ($segment->getDynamicFilters() as $dynamicFilter) {
+      $missingPlugin = $this->getMissingPluginByFilter($dynamicFilter);
+      if (!$missingPlugin) {
+        continue;
+      }
+      $missingPlugins[] = $missingPlugin['name'];
+    }
+    return $missingPlugins;
+  }
+
+  public function getMissingPluginByFilter(DynamicSegmentFilterEntity $dynamicSegmentFilter): ?array {
+    $requiredPlugin = $this->getRequiredPluginName($dynamicSegmentFilter);
+    if (isset($requiredPlugin['id']) && !$this->wp->isPluginActive($requiredPlugin['id'])) {
+      return $requiredPlugin;
+    }
+    return null;
+  }
+
+  private function getRequiredPluginName(DynamicSegmentFilterEntity $dynamicSegmentFilter): ?array {
+    if (isset(self::REQUIRED_PLUGINS_BY_TYPE[$dynamicSegmentFilter->getFilterData()->getFilterType()])) {
+      return self::REQUIRED_PLUGINS_BY_TYPE[$dynamicSegmentFilter->getFilterData()->getFilterType()];
+    }
+
+    return null;
+  }
+}
diff --git a/views/segments.html b/views/segments.html
index ca6d7e9af0..3e53ce4e54 100644
--- a/views/segments.html
+++ b/views/segments.html
@@ -117,6 +117,7 @@
     'nameColumn': __('Name'),
     'subscribersCountColumn': __('Number of subscribers'),
     'updatedAtColumn': __('Modified on'),
+    'missingPluginMessageColumn': __('Missing plugin message'),
     'loadingDynamicSegmentItems': __('Loading data…'),
     'noDynamicSegmentItemsFound': __('No segments found'),
     'numberOfItemsSingular': __('1 item'),